故事背景是发生在1895的加拿大，主人公默多克是个年轻英俊的侦探，他的破案手段在当时看来都是非传统的，但却破获了一宗又一宗案件，他的上司虽然对他破案手法不屑一顾，但每次破案后又对自己有这么一个下属感到沾沾自喜，但病理学家却对默多克的破案手法很是欣赏，同时为他破案也提供很多帮助，而默多克也对她日渐迷恋，但又难以启齿.....
Season five of Murdoch Mysteries opens in unfamiliar territory, as Detective William Murdoch (Yannick Bisson) leaves Toronto to try his luck while the Klondike Gold Rush in the Yukon winds down. Suspended for interfering in an investigation, on the run for surreptitiously freeing a murderer to make amends, and nursing a broken heart after Dr. Ogden's marriage to another man, he tries to escape his past, and his passion for detective work. Back in the city, newly promoted Chief Constable Giles (Nigel Bennett) makes it clear to Inspector Thomas Brackenreid (Thomas Craig), that he'll be keeping a very close eye on police matters. Meanwhile, Murdoch's beloved former associate, Dr. Julia Ogden (Hélène Joy), is now working alongside Acting Detective George Crabtree (Jonny Harris) and Dr. Emily Grace (Georgina Reilly), a feisty young protégé. In the remote north, Murdoch is pleased to discover that his fledgling prospecting career may garner great success, a small comfort after Julia's marriage to another man. But as he tries to rebuild his life, he finds himself drawn into the case of Mrs. Elizabeth Bryant (Jill Halfpenny), an innkeeper charged with murder. The plot thickens when writer Jack London (Aaron Ashmore) lends his insights, and Murdoch soon realizes that while he had hoped to leave his shattered heart and tattered career back in Toronto, his days as a detective are not behind him.
